The study design is summarized in Figure 1. The ablation catheter has been described in detail elsewhere ( 7, 8). This prospective, multicenter, nonrandomized clinical study was designed to evaluate the safety and effectiveness of the STSF catheter in the treatment of drug-refractory symptomatic PsAF compared with predetermined performance goals. investigational device exemption (IDE) clinical study designed to evaluate the safety and effectiveness of catheter ablation in patients with PsAF using the THERMOCOOL SMARTTOUCH SF (STSF) catheter (Biosense Webster, Inc., Irvine, California) porous tip CF catheter ( Central Illustration). The PRECEPT (Prospective Review of the Safety and Effectiveness of the THERMOCOOL SMARTTOUCH SF Catheter Evaluated for Treating Symptomatic PersistenT AF) study ( NCT02817776) is the first prospective, multicenter U.S. To date, there is no ablation catheter approved by the Food and Drug Administration for PsAF. Although approximately one-third of AF catheter ablation procedures worldwide are currently performed for persistent or long-standing persistent AF, there are currently limited data on the outcomes of AF ablation in patients with nonparoxysmal AF ( 1, 5).
The increased AF burden resulting from PsAF is associated with a higher risk of stroke, heart failure, and mortality compared with paroxysmal AF ( 6). In a significant portion of patients, paroxysmal AF progresses to more chronic forms of arrhythmia, including persistent atrial fibrillation (PsAF), defined as AF that continues beyond 7 days ( 5). The superiority of catheter ablation of drug-resistant paroxysmal AF in comparison to antiarrhythmic drug (AAD) therapy has been well established, with continued improvements in success rates demonstrated over the past decade with advancement in ablation technologies, especially after the introduction of contact force (CF)–sensing catheters ( 1–4). 194).Radiofrequency (RF) catheter ablation therapy, with the aim of achieving electrical isolation of the pulmonary veins (PVs), is the cornerstone of treatment for atrial fibrillation (AF) ( 1). 1990 (5) Konrad Müller, ed., Petroni Arbitri Satyricon cum Apparatu Critico (Munich: Heimeran, 1961 2d ed.: Leipzig: Teubner, 1965 3d ed.: Leipzig: Teubner, 1983 4th ed.: Petronii Arbitri Satyricon Reliquiae (Stuttgart: Teubner 1995) the latter edition has a new Praefatio (iii-xlviii) and an expanded section of Fragmenta (pp. Le Satiricon: Texte établi et traduit par Alfred Ernout (Paris: Les Belles Lettres, 1923 rev. Baehrens Leipzig: Teubner, 1882), 98, no. Leipzig: Teubner, 1894–1906) (3) Emil Baehrens, ed., Excerpta ex Petronio (vol. Stuckey, A Bibliography of Petronius (Leiden: Brill, 1977), 20–21 (2) Alexander Riese, ed., Anthologia Latina, vol. Bücheler’s editio maior still has the most complete apparatus criticus and represents the most authoritative of the ‘conservative’ texts,” so Gareth L. For his magnum opus Bücheler “returned to the whole range of manuscripts, searched out new ones, did his own collating, and relied upon his superior skills as a grammarian and acute thinker. 47 ( editio maior) 2d and 3d ed., Berlin: Weidmann, 18. (1) Franz Bücheler, ed., Petronii Arbitri Satirarum Reliquiae Ex Recensione Francisci Buecheleri.
47 ( editio maior ) 2d and 3d ed., Berlin: Weidmann, 18. , Petronii Arbitri Satirarum Reliquiae Ex Recensione Francisci Buecheleri.
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